Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylate → Ethyl 4,5-bis(3-chlorophenyl)furan-2-carboxylate

HRID 2190120ノート

反応式

HRID 2190120 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16](C#N)[CH:15]=2)[CH:5]=[C:6](F)[CH:7]=1.BrC1C=C(C(OCC)=O)OC=1C1C=CC=C([Cl:39])C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:39])[CH:15]=2)[CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 58064772Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylateHCID 58064795Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

生成物 1

HCID 58064774Ethyl 4,5-bis(3-chlorophenyl)furan-2-carboxylate

実験手順

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 11A starting with the compound from Example 5A. Extraction is carried out with dichloromethane and purification is by preparative HPLC (RP18 column; eluent: acetonitrile/water gradient). 452 mg (34% of theory) of the title compound are obtained.

後処理

  1. extractionExtraction
  2. customis carried out with dichloromethane and purification

出典と根拠

ORDレコード
ord-8fded2013afd4d1f818084ddb25f86df
出典データセット
uspto-grants-2012_12
特許番号
US08324268B2

反応ノート

読み込み中…