Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-chloro-5-fluorophenyl)furan-2-carboxylate → 5-(3-Chloro-4-fluorophenyl)-4-(3-chloro-5-fluorophenyl)furan-2-carboxylic acid

HRID 2190125ノート

反応式

HRID 2190125 の反応式
ClC1C=C(C2C=C(C(O)=O)OC=2C2C=CC=C(C#N)C=2)C=C(F)C=1.[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[O:37][C:36]([C:38]([O:40]CC)=[O:39])=[CH:35][C:34]=2[C:43]2[CH:48]=[C:47]([F:49])[CH:46]=[C:45]([Cl:50])[CH:44]=2)[CH:29]=[CH:30][C:31]=1[F:32]>>[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[O:37][C:36]([C:38]([OH:40])=[O:39])=[CH:35][C:34]=2[C:43]2[CH:48]=[C:47]([F:49])[CH:46]=[C:45]([Cl:50])[CH:44]=2)[CH:29]=[CH:30][C:31]=1[F:32]

参加物

3

反応物 2

HCID 58064790Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-chloro-5-fluorophenyl)furan-2-carboxylateHCID 580647984-(3-Chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylic acid

生成物 1

HCID 580647965-(3-Chloro-4-fluorophenyl)-4-(3-chloro-5-fluorophenyl)furan-2-carboxylic acid

実験手順

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 20A starting with the compound from Example 12A. The crude product obtained after extraction is dried under high vacuum and reacted further without chromatographic purification. 0.65 g (80% of theory) of the title compound with a purity of 75% are obtained.

後処理

  1. customThe crude product obtained
  2. extractionafter extraction
  3. customis dried under high vacuum
  4. customreacted further without chromatographic purification

出典と根拠

ORDレコード
ord-e5f74045d968450aaa68cfd764edc0a5
出典データセット
uspto-grants-2012_12
特許番号
US08324268B2

反応ノート

読み込み中…