Ethyl 5-bromo-4-(3-chlorophenyl)furan-2-carboxylate → 5-Bromo-4-(3-chlorophenyl)furan-2-carboxylic acid

HRID 2190126ノート

反応式

HRID 2190126 の反応式
ClC1C=C(C2C=C(C(O)=O)OC=2C2C=CC=C(C#N)C=2)C=C(F)C=1.[Br:25][C:26]1[O:30][C:29]([C:31]([O:33]CC)=[O:32])=[CH:28][C:27]=1[C:36]1[CH:41]=[CH:40][CH:39]=[C:38]([Cl:42])[CH:37]=1>>[Br:25][C:26]1[O:30][C:29]([C:31]([OH:33])=[O:32])=[CH:28][C:27]=1[C:36]1[CH:41]=[CH:40][CH:39]=[C:38]([Cl:42])[CH:37]=1

参加物

3

反応物 2

HCID 58064768Ethyl 5-bromo-4-(3-chlorophenyl)furan-2-carboxylateHCID 580647984-(3-Chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylic acid

生成物 1

HCID 580648025-Bromo-4-(3-chlorophenyl)furan-2-carboxylic acid

実験手順

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 20A starting with the compound from Example 18A. The crude product obtained after extraction is dried under high vacuum and reacted further without chromatographic purification. 47.0 mg (86% of theory) of the title compound are obtained.

後処理

  1. customThe crude product obtained
  2. extractionafter extraction
  3. customis dried under high vacuum
  4. customreacted further without chromatographic purification

出典と根拠

ORDレコード
ord-d95bb25cf0934d10b758a3700952141b
出典データセット
uspto-grants-2012_12
特許番号
US08324268B2

反応ノート

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