Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylate → 4-Bromo-5-(3-chlorophenyl)furan-2-carboxylic acid

HRID 2190127ノート

反応式

HRID 2190127 の反応式
ClC1C=C(C2C=C(C(O)=O)OC=2C2C=CC=C(C#N)C=2)C=C(F)C=1.[Br:25][C:26]1[CH:27]=[C:28]([C:38]([O:40]CC)=[O:39])[O:29][C:30]=1[C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[CH:32]=1>>[Br:25][C:26]1[CH:27]=[C:28]([C:38]([OH:40])=[O:39])[O:29][C:30]=1[C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[CH:32]=1

参加物

3

反応物 2

HCID 58064772Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylateHCID 580647984-(3-Chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylic acid

生成物 1

HCID 580647974-Bromo-5-(3-chlorophenyl)furan-2-carboxylic acid

実験手順

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 20A starting with the compound from Example 5A. Instead of using ethyl acetate, the crude product is extracted with dichloromethane and reacted further without chromatographic purification. 447 mg (98% of theory) of the title compound are obtained.

後処理

  1. extractionInstead of using ethyl acetate, the crude product is extracted with dichloromethane
  2. customreacted further without chromatographic purification

出典と根拠

ORDレコード
ord-99678ff6324c49449c7f0cf733311f55
出典データセット
uspto-grants-2012_12
特許番号
US08324268B2

反応ノート

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