4-{[4-Bromo-5-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-one → 4-{[5-Bromo-4-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-one
反応式
BrC1C=C(C([N:16]2[CH2:21][CH2:20][NH:19][C:18](=[O:22])[CH2:17]2)=O)OC=1C1C=CC=C(Cl)C=1.[Br:23][C:24]1[O:28][C:27]([C:29]([OH:31])=O)=[CH:26][C:25]=1[C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([Cl:38])[CH:33]=1>>[Br:23][C:24]1[O:28][C:27]([C:29]([N:16]2[CH2:21][CH2:20][NH:19][C:18](=[O:22])[CH2:17]2)=[O:31])=[CH:26][C:25]=1[C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([Cl:38])[CH:33]=1参加物
3
実験手順
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 27A starting with the compound from Example 22A. 48.0 mg (79% of theory) of the title compound are obtained.
出典と根拠
- ORDレコード
- ord-c968acfb4bae494e8655befc1d8781c9
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08324268B2
反応ノート
読み込み中…