3-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile → 3-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile

HRID 2190146ノート

反応式

HRID 2190146 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][C:11]([C:23]([N:25]3[CH2:29][C:28](=[O:30])[NH:27][CH2:26]3)=[O:24])=[CH:12][C:13]=2[C:14]2[CH:15]=[C:16]([C:21]#[N:22])[CH:17]=[C:18]([F:20])[CH:19]=2)[CH:5]=[CH:6][C:7]=1F.ClC1C=C(C2OC(C(OCC)=O)=CC=2C2C=C(F)C=C(C#N)C=2)C=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][C:11]([C:23]([N:25]3[CH2:29][C:28](=[O:30])[NH:27][CH2:26]3)=[O:24])=[CH:12][C:13]=2[C:14]2[CH:15]=[C:16]([C:21]#[N:22])[CH:17]=[C:18]([F:20])[CH:19]=2)[CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 580647863-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrileHCID 58064792Ethyl 5-(3-chlorophenyl)-4-(3-cyano-5-fluorophenyl)furan-2-carboxylate

生成物 1

HCID 468334843-{2-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile

実験手順

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 31 starting with the compound from Example 16A. 29.9 mg (49% of theory) of the title compound are obtained.

出典と根拠

ORDレコード
ord-6a48b52fcbdf40d9b055fce716345d0b
出典データセット
uspto-grants-2012_12
特許番号
US08324268B2

反応ノート

読み込み中…