4-(Trifluoromethyl)phenylboronic acid → 4-Hydroxy-2-oxo-6-(4-trifluoromethyl-phenyl)-2H-chromene-3-carboxylic acid methyl ester
反応式
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[O:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][C:11](Br)=[CH:10][CH:9]=2)=[O:4].[F:18][C:19]([F:30])([F:29])[C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[O:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][C:11]([C:23]1[CH:24]=[CH:25][C:20]([C:19]([F:30])([F:29])[F:18])=[CH:21][CH:22]=1)=[CH:10][CH:9]=2)=[O:4]参加物
3
実験手順
4-Hydroxy-2-oxo-6-(4-trifluoromethyl-phenyl)-2H-chromene-3-carboxylic acid methyl ester was prepared from 6-bromo-4-hydroxy-2-oxo-2H-chromene-3-carboxylic acid methyl ester and 4-(trifluoromethyl)phenylboronic acid under conditions analogous to example 3-a. MS ESI(+) m/e: 365 (M+1).
出典と根拠
- ORDレコード
- ord-6656c0a0d57a47d3a8afd45d3bc2a082
- 出典データセット
- uspto-grants-2012_12