Diethyl Ether → HCID 86634464、化合物

HRID 2191168ノート

反応式

HRID 2191168 の反応式
[CH:1]1([C:4](=[O:9])[CH2:5][CH2:6][CH2:7][OH:8])[CH2:3][CH2:2]1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.C(OCC)C>ClCCl>[CH:1]1([C:4](=[O:9])[CH2:5][CH2:6][CH:7]=[O:8])[CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 3283Diethyl Ether2 回HCID 1572618325979-84-4HCID 178418287HCID 178418287、化合物

生成物 1

HCID 86634464HCID 86634464、化合物収率 78%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

230 mg (1.79 mmol) of 1-cyclopropyl-4-hydroxy-1-butanone was dissolved in 7 ml of dichloromethane, and 580 mg (2.69 mmol) of pyridinium chlorochromate was added thereto, followed by stirring for 1 hour at room temperature. To the reaction solution was added diethyl ether, the mixture was filtered using Celite, and the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (solvent; diethyl ether alone) to give 176 mg of the title compound as a pale yellow oil (yield: 78%).

後処理

  1. filtrationthe mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-602d82a54fd647ea8d9b76e7f662a3dd
出典データセット
uspto-grants-2012_12
特許番号
USRE043858E1

反応ノート

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