5-Bromoisatoic Anhydride → 6-bromoquinazolin-4-ol
反応式
[Br:1][C:2]1[CH:13]=[C:6]2[C:7](O[C:10](=O)[NH:11][C:5]2=[CH:4][CH:3]=1)=[O:8].C([O-])(=O)C.C(N)=[NH2+:19]>CC(O)C>[Br:1][C:2]1[CH:13]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:11]=[CH:10][NH:19][C:7]2=[O:8]参加物
4
実験手順
A solution of 5-bromoisatoic anhydride (5.0 g, 21 mmol) and formamidinium acetate (2.2 g, 21 mmol) in 60 mL of i-PrOH was heated at reflux for 10 hours. The reaction mixture was cooled to rt and the white solid was collected by filtration. The white solid was washed with small amount of i-PrOH and dried in air to give desired product 6-bromoquinazolin-4(3H)-one. MS (ESI, pos. ion) m/z: 224.9 (M+1).
後処理
- temperatureat reflux for 10 hours
- filtrationthe white solid was collected by filtration
- washThe white solid was washed with small amount of i-PrOH
- customdried in air
出典と根拠
- ORDレコード
- ord-638eb79c0919478f92004a860c9e5382
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08198448B2
反応ノート
読み込み中…