Hydrochloric Acid → 1350473-55-0

HRID 2191592ノート

反応式

C(OC(=O)[NH:7][C:8]1([C:13]([CH:15]2[CH2:17][CH2:16]2)=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9]1)(C)(C)C.CO.[ClH:21]>>[ClH:21].[NH2:7][C:8]1([C:13]([CH:15]2[CH2:17][CH2:16]2)=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9]1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 67002375HCID 67002375、化合物

生成物 1

HCID 670020501350473-55-0収率 98%

実験手順

In a 10 mL round-bottomed flask (1-cyclopropanecarbonyl-cyclopentyl)-carbamic acid tert-butyl ester (61 mg, 0.24 mmol) was dissolved in 1.0 M HCl solution in MeOH (1.5 mL, 1.5 mmol). The reaction mixture was stirred at room temperature overnight then concentrated under reduced pressure to afford 45 mg (98%) of (1-amino-cyclopentyl)-cyclopropyl-methanone hydrochloride as a white solid.

後処理

concentrationthen concentrated under reduced pressure

出典と根拠

ORDレコード: ord-9812656e644648a8b9d6765215e936ea
出典データセット: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08329699B2

反応ノート

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