関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetamide | HCID 178 | — |
| 反応物 | Potassium Fluoride | HCID 522689 | — |
| 反応物 | methyl 6-benzoyloxy-2(RS)-bromohexanoate | HCID 15222235 | — |
| 生成物 | methyl 6-benzoyloxy-2(RS)-fluorohexanoate | HCID 15224608 | — |
| 生成物 | Methyl 6-benzoyloxyhexanoate | HCID 19930972 | 58.3% |
反応手順
A mixture of methyl 6-benzoyloxy-2(RS)-bromo-hexanoate (e) (14.02 g), potassium fluoride (12.59 g) and acetamide (12.3 g) was stirred at 105° C. for 6 hours. The crude product obtained by treating in the conventional manner was subjected to silica gel chromatography to give the title compound (f) and methyl 6-benzoyloxyhexanoate (g) (3.11 g, yield: 29%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05426115 |
|---|
| 出典データセット | uspto-grants-1995_06 |
|---|
| ORD ID | ord-beec5d027b5441a18961f0be48c28101 |
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| 出典メモ | uspto-grants-1995_06 |
|---|
