CID 6037 → HCID 178484386、化合物

HRID 2191896

反応式

HRID 2191896 の反応式
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[CH:10]1[C:15]([C:16]([NH:18][C@H:19]([C:25]([OH:27])=[O:26])[CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[O:17])=[CH:14][CH:13]=[C:12]([NH:28][CH2:29][C:30]2[CH:31]=[N:32][C:33]3[NH:40][C:39]([NH2:41])=[N:38][C:36](=[O:37])[C:34]=3[N:35]=2)[CH:11]=1>C(O)C>[CH:14]1[C:15]([C:16]([NH:18][C@H:19]([C:25]([OH:27])=[O:26])[CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[O:17])=[CH:10][CH:11]=[C:12]([NH:28][CH2:29][C:30]2[CH:31]=[N:32][C:33]3[NH:40][C:39]([NH2:41])=[N:38][C:36](=[O:37])[C:34]=3[N:35]=2)[CH:13]=1.[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3]

参加物

4

反応物 2

HCID 6037CID 6037HCID 178484382HCID 178484382、化合物2 回

生成物 1

HCID 178484386HCID 178484386、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒3 回

実験手順

Under nitrogen gas, 150 mL fresh ethanol was added to the free base of metformin in ethanol, and to the free base of metformin in ethanol was slowly added 42 g (0.095 eq.) folacin solid. At that time the temperature of the reaction mixture began to ascend. The reaction was stirred and the adding speed was controlled to keep the reaction temperature not exceeding 50° C. Stirring was continued until the solid was substantially dissolved. When new solid began to present, ⅔-⅘ volume of solvent was removed under reduced pressure, and the reaction was cooled to ambient temperature to give the crude product of folacin-metformin compound.

後処理

  1. customexceeding 50° C
  2. stirringStirring
  3. dissolutionwas substantially dissolved
  4. custom⅔-⅘ volume of solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-ea37497c9b484071a21980134ca89a4a
出典データセット
uspto-grants-2012_12
特許番号
US08329710B2

関連ノート

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