Ethyl orthoformate → 5-Fluorobenzimidazole

HRID 2191924ノート

反応式

HRID 2191924 の反応式
[F:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.[CH2:10](OC(OCC)OCC)C>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]2[N:8]=[CH:10][NH:9][C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 31214Ethyl orthoformateHCID 1645844-Fluorobenzene-1,2-diamine

生成物 1

HCID 2356985-Fluorobenzimidazole

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
150 °C

実験手順

To the solution of 4-fluoro-benzene-1,2-diamine (10 g, 79.4 mmol) and triethylorthoformate (117 mL, 793 mmol) was added few drop of ethanol and the reaction mixture was refluxed at 150° C. overnight. The reaction mixture was concentrated and the residue was directly taken to the next step. [M+H]=137.

後処理

  1. concentrationThe reaction mixture was concentrated

出典と根拠

ORDレコード
ord-f2ff2e146fad4178aa5667e0c91fe0c0
出典データセット
uspto-grants-2012_12
特許番号
US08329700B2

反応ノート

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