Boron tribromide → 2-(7-hydroxyquinolin-4-yloxy)acetic Acid Hydrobromide

HRID 219210ノート

反応式

HRID 219210 の反応式
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.B(Br)(Br)[Br:19]>ClCCCl.C(Cl)Cl>[BrH:19].[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 25134Boron tribromideHCID 576910212-(7-Methoxyquinolin-4-yloxy)acetic acid

生成物 1

HCID 1363301242-(7-hydroxyquinolin-4-yloxy)acetic Acid Hydrobromide収率 139.8%

試薬・触媒・溶媒 2

HCID 111,2-Dichloroethane溶媒HCID 6344Dichloromethane溶媒

実験手順

To a pressure vial was added 2-(7-methoxyquinolin-4-yloxy)acetic acid (1.00 g, 4.29 mmol) in DCE (0.6 M, 7 mL). The vial was cooled in an ice bath and to the solution was added BBr3 (1.62 ml, 17.2 mmol). The reaction was allowed to warm to room temperature and stirred overnight. While some starting material remained, the reaction was stopped and diluted with DCM (keep in hood due to fuming). The solids were filtered and dried over high vacuum to yield a light brown crude solid (˜1.8 g). The material was used without further purification.

後処理

  1. temperatureThe vial was cooled in an ice bath and to the solution
  2. filtrationThe solids were filtered
  3. customdried over high vacuum

出典と根拠

ORDレコード
ord-39dda22102f24e7daa033420728d9aa9
出典データセット
uspto-grants-2012_06
特許番号
US08198448B2

反応ノート

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