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Ammonium Chloride → 2-(4,4-Dimethyl-3,4-dihydroquinolin-1(2H)-yl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 4,4-Dimethyl-1-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline | HCID 57423310 | — |
| 触媒 | Zinc | HCID 23994 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(4,4-Dimethyl-3,4-dihydroquinolin-1(2H)-yl)aniline | HCID 59337707 | 73% |
反応手順
The crude 1c (0.66 g) was stirred in MeOH (20 mL) at rt. Solid NH4Cl (0.62 g) was added, followed by addition of Zn dust (3.0 g) portionwise. The resulting mixture was stirred at rt for 2 h. It was filtered through Celite®, rinsed with CH2Cl2, and concentrated to dryness. The residue was purified by flash chromatography (hexanes/EtOAc) to give pure amine 1d (0.43 g, 73% for two steps). LC-MS ESI 253 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08329718B2 |
| 出典データセット | uspto-grants-2012_12 |
| ORD ID | ord-766cb1a34b974b689e5e6e5f8a63d2f9 |
| 出典メモ | uspto-grants-2012_12 |