Hydrochloric Acid → Methyl 1-phenylcycloheptanecarboxylate
反応式
[C:1]1([C:7]2([C:14]([OH:16])=[O:15])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:18]O>>[CH3:18][O:15][C:14]([C:7]1([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1)=[O:16]参加物
4
実験手順
1-Phenyl-cycloheptanecarboxylic acid (Example 1c) (4.15 g) was refluxed in methanol (150 mL) and concentrated hydrochloric acid (5 mL) for 24 hours. The solvent was evaporated and the residue was dissolved in ether (100 mL) which was washed with water (100 mL), saturated sodium bicarbonate (50 mL) and water (100 mL), dried (MgSO4) and evaporated to afford the sub-titled compound (3.5 g) as an oil.
後処理
- customThe solvent was evaporated
- dissolutionthe residue was dissolved in ether (100 mL) which
- washwas washed with water (100 mL), saturated sodium bicarbonate (50 mL) and water (100 mL)
- dry with materialdried (MgSO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-a446091158ed48bea5ddf838da65ce89
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08329729B2
反応ノート
読み込み中…