Morpholine → 1-Methyl-5-(5-morpholinoacetyl-2-n-propoxyphenyl)-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

HRID 21925

反応式

HRID 21925 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]([C:11]1[CH:12]=[CH:13][C:14]([O:31][CH2:32][CH2:33][CH3:34])=[C:15]([C:17]2[NH:18][C:19](=[O:30])[C:20]3[N:25]([CH3:26])[N:24]=[C:23]([CH2:27][CH2:28][CH3:29])[C:21]=3[N:22]=2)[CH:16]=1)=[O:10]>>[CH3:26][N:25]1[C:20]2[C:19](=[O:30])[NH:18][C:17]([C:15]3[CH:16]=[C:11]([C:9](=[O:10])[CH2:8][N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)[CH:12]=[CH:13][C:14]=3[O:31][CH2:32][CH2:33][CH3:34])=[N:22][C:21]=2[C:23]([CH2:27][CH2:28][CH3:29])=[N:24]1

参加物

3

反応物 2

HCID 8083MorpholineHCID 1361616085-(5-Bromoacetyl-2-n-propoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one

生成物 1

HCID 1354308571-Methyl-5-(5-morpholinoacetyl-2-n-propoxyphenyl)-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one収率 47%

実験手順

This compound was prepared from morpholine and 5-(5-bromoacetyl-2-n-propoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (Preparation 11), following the procedure of Example 1, and was obtained as white crystals (47%), m.p. 128°-129° C. Found: C,63.62; H,7.07; N,15.53. C24H31N5O4 requires C,63.56; H,6.89; N,15.44%.

出典と根拠

ORDレコード
ord-8cc032221e9742b4b954ca06c1638add
出典データセット
uspto-grants-1995_06
特許番号
US05426107

関連ノート

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