Hydrochloric Acid → HCID 66876379、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:26]=[CH:25][CH:24]=[C:23]4[C:18]=3[CH:19]=[CH:20][N:21]=[C:22]4[NH:27][CH2:28][CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[N:13]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH:9]([CH3:11])[CH3:10].Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:26]=[CH:25][CH:24]=[C:23]4[C:18]=3[CH:19]=[CH:20][N:21]=[C:22]4[NH:27][CH2:28][CH2:29][C:30]([OH:32])=[O:31])[N:13]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH:9]([CH3:11])[CH3:10]参加物
4
反応条件
- 温度
- 50 °C
実験手順
1,1-Dimethylethyl N-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-β-alaninate (D9; 20 mg, 0.039 mmol) and 0.5M HCl in 1,4-dioxane (10 ml) were stirred at room temperature for 2.5 h. The reaction mixture was then heated to 50° C. for a further 30 minutes, cooled and evaporated to dryness. The resulting solid was triturated with ether and 1,4-dioxane to yield the title compound (20 mg) as a white solid.