Hydrogen chloride-ethyl acetate → HCID 68432330、化合物

HRID 2192786ノート

反応式

HRID 2192786 の反応式
[NH2:1][C:2]([C@@H:4]1[CH2:9][C@H:8]([N:10]([C:15]([C:17]2[C:18]([NH:27][CH2:28][C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[N:19][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[N:21][CH:22]=2)=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])[CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5]1)=[O:3].C(OCC)(=O)C.[ClH:47]>>[ClH:47].[ClH:47].[NH2:1][C:2]([C@@H:4]1[CH2:5][NH:6][CH2:7][C@H:8]([N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:15]([C:17]2[C:18]([NH:27][CH2:28][C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[N:19][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[N:21][CH:22]=2)=[O:16])[CH2:9]1)=[O:3]

参加物

3

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59625490tert-butyl (3R*,5S*)-3-(aminocarbonyl)-5-[({2-tert-butyl-4-[(2-furylmethyl)amino]pyrimidin-5-yl}carbonyl)(isobutyl)amino]piperidine-1-carboxylate

生成物 1

HCID 68432330HCID 68432330、化合物

実験手順

tert-Butyl (3R*,5S*)-3-(aminocarbonyl)-5-[({2-tert-butyl-4-[(2-furylmethyl)amino]pyrimidin-5-yl}carbonyl)(isobutyl)amino]piperidine-1-carboxylate (230 mg) was dissolved in 1 M hydrogen chloride-ethyl acetate (4 ml), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated, ethyl acetate was added and the precipitate was collected by filtration and washed with ethyl acetate to give the object compound (218 mg).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additionethyl acetate was added
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-3ef6f23b6d3d44dabd872fffb81d7810
出典データセット
uspto-grants-2012_12
特許番号
US08329691B2

反応ノート

読み込み中…