Hydrogen chloride-ethyl acetate → 2-tert-butyl-N-{(3S,5R)-5-[(4-methoxypiperidin-1-yl)carbonyl]piperidin-3-yl}-4-[(3-methoxypropyl)amino]-N-(2-methylpropyl)pyrimidine-5-carboxamide dihydrochloride

HRID 2192868ノート

反応式

HRID 2192868 の反応式
[C:1]([C:5]1[N:10]=[C:9]([NH:11][CH2:12][CH2:13][CH2:14][O:15][CH3:16])[C:8]([C:17]([N:19]([CH2:43][CH:44]([CH3:46])[CH3:45])[C@H:20]2[CH2:25][C@@H:24]([C:26]([N:28]3[CH2:33][CH2:32][CH:31]([O:34][CH3:35])[CH2:30][CH2:29]3)=[O:27])[CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]2)=[O:18])=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].C(OCC)(=O)C.[ClH:53]>C(OCC)(=O)C>[ClH:53].[ClH:53].[C:1]([C:5]1[N:10]=[C:9]([NH:11][CH2:12][CH2:13][CH2:14][O:15][CH3:16])[C:8]([C:17]([N:19]([C@H:20]2[CH2:25][C@@H:24]([C:26]([N:28]3[CH2:33][CH2:32][CH:31]([O:34][CH3:35])[CH2:30][CH2:29]3)=[O:27])[CH2:23][NH:22][CH2:21]2)[CH2:43][CH:44]([CH3:46])[CH3:45])=[O:18])=[CH:7][N:6]=1)([CH3:3])([CH3:4])[CH3:2]

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59625327tert-butyl (3S,5R)-3-[({2-tert-butyl-4-[(3-methoxypropyl)amino]pyrimidin-5-yl}carbonyl)(2-methylpropyl)amino]-5-[(4-methoxypiperidin-1-yl)carbonyl]piperidine-1-carboxylate

生成物 1

HCID 684328672-tert-butyl-N-{(3S,5R)-5-[(4-methoxypiperidin-1-yl)carbonyl]piperidin-3-yl}-4-[(3-methoxypropyl)amino]-N-(2-methylpropyl)pyrimidine-5-carboxamide dihydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

tert-Butyl (3S,5R)-3-[({2-tert-butyl-4-[(3-methoxypropyl)amino]pyrimidin-5-yl}carbonyl)(2-methylpropyl)amino]-5-[(4-methoxypiperidin-1-yl)carbonyl]piperidine-1-carboxylate (65 mg) was dissolved in ethyl acetate (5 ml), 4 N hydrogen chloride-ethyl acetate solution (7 ml) was added, and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and the residue was dried under reduced pressure to give the object compound (57 mg).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was dried under reduced pressure

出典と根拠

ORDレコード
ord-10d8debf53f6449fb1d08cf5328c3672
出典データセット
uspto-grants-2012_12
特許番号
US08329691B2

反応ノート

読み込み中…