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Ethyl Acetate → 7-methoxy-N-methyl-1-(2-(4-((naphthalen-2-ylmethyl)amino)piperidin-1-yl)ethyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide hydrochloride

HRID 2193329
ノート
印刷プレビュー

反応式

HRID 2193329 の反応式
C(OCC)(=O)C.[CH3:7][O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([C:40]([NH:42][CH3:43])=[O:41])=[CH:14][C:15](=[O:39])[N:16]2[CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][CH:24]([NH:27][CH2:28][C:29]3[CH:38]=[CH:37][C:36]4[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=4)[CH:30]=3)[CH2:23][CH2:22]2)=[CH:11][CH:10]=1.[ClH:44].C(OCC)(=O)C>CO>[ClH:44].[CH3:7][O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([C:40]([NH:42][CH3:43])=[O:41])=[CH:14][C:15](=[O:39])[N:16]2[CH2:19][CH2:20][N:21]2[CH2:22][CH2:23][CH:24]([NH:27][CH2:28][C:29]3[CH:38]=[CH:37][C:36]4[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=4)[CH:30]=3)[CH2:25][CH2:26]2)=[CH:11][CH:10]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 21866389Hydrogen chloride-ethyl acetateHCID 593983767-methoxy-N-methyl-1-(2-(4-((naphthalen-2-ylmethyl)amino)piperidin-1-yl)ethyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide

生成物 1

HCID 675386827-methoxy-N-methyl-1-(2-(4-((naphthalen-2-ylmethyl)amino)piperidin-1-yl)ethyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide hydrochloride

試薬・触媒・溶媒 1

HCID 887
Methanol
溶媒

実験手順

To a mixed solution of 1 mL ethyl acetate and 2 mL methanol containing 0.20 g of 7-methoxy-N-methyl-1-(2-(4-((naphthalen-2-ylmethyl)amino)piperidin-1-yl)ethyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added at room temperature, and the solvent was removed under reduced pressure. Ethyl acetate was added to the residue thus obtained, and the resulting solid was filtered to give 0.16 g of 7-methoxy-N-methyl-1-(2-(4-((naphthalen-2-ylmethyl)amino)piperidin-1-yl)ethyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide hydrochloride as a pale yellow solid.

後処理

  1. customthe solvent was removed under reduced pressure
  2. additionEthyl acetate was added to the residue
  3. customthus obtained
  4. filtrationthe resulting solid was filtered

出典と根拠

ORDレコード
ord-114c60b083db4297a26d6ded4baed786
出典データセット
uspto-grants-2012_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08329694B2

反応ノート

読み込み中…

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