Hydrogen chloride-ethyl acetate → 1-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide hydrochloride

HRID 2193331

反応式

HRID 2193331 の反応式
[CH2:1]([C:3]1[CH:35]=[CH:34][C:6]([CH2:7][NH:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:27][CH3:28])[CH:25]=4)[C:20]([C:29]([NH:31][CH3:32])=[O:30])=[CH:19][C:18]3=[O:33])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[ClH:36].C(OCC)(=O)C>CO>[ClH:36].[CH2:1]([C:3]1[CH:35]=[CH:34][C:6]([CH2:7][NH:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][N:17]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:27][CH3:28])[CH:25]=4)[C:20]([C:29]([NH:31][CH3:32])=[O:30])=[CH:19][C:18]3=[O:33])[CH2:13][CH2:14]2)=[CH:5][CH:4]=1)[CH3:2]

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593980151-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide

生成物 1

HCID 675376111-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 2 mL of a methanol solution containing 0.14 g of 1-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added at room temperature, and the solvent was removed under reduced pressure. Ethyl acetate was added to the residue thus obtained, and the resulting solid was filtered to give 0.15 g of 1-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide hydrochloride as a pale yellow solid.

後処理

  1. additionwas added at room temperature
  2. customthe solvent was removed under reduced pressure
  3. additionEthyl acetate was added to the residue
  4. customthus obtained
  5. filtrationthe resulting solid was filtered

出典と根拠

ORDレコード
ord-737e5b578a294babacbe675aa7a45975
出典データセット
uspto-grants-2012_12
特許番号
US08329694B2

関連ノート

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