[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:34])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]3[CH:24]=[CH:25][C:26]4[O:27][CH2:28][C:29](=[O:33])[NH:30][C:31]=4[N:32]=3)[CH2:17][CH2:16]2)=[CH:5][CH:4]=1.[ClH:35].C(OCC)(=O)C>CO>[ClH:35].[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:34])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]3[CH:24]=[CH:25][C:26]4[O:27][CH2:28][C:29](=[O:33])[NH:30][C:31]=4[N:32]=3)[CH2:17][CH2:16]2)=[CH:5][CH:4]=1To 3 mL of a methanol solution containing 202 mg of 7-methoxy-1-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and the solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 209 mg of 7-methoxy-1-(2-(4-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride as a pale yellow powder.
読み込み中…