Hydrochloric Acid → 3-(Pent-2-en-3-yl)-2,2'-bitiophene

HRID 2193808ノート

反応式

HRID 2193808 の反応式
[S:1]1[CH:5]=[CH:4][C:3]([C:6](O)([CH2:9][CH3:10])[CH2:7][CH3:8])=[C:2]1[C:12]1[S:13][CH:14]=[CH:15][CH:16]=1.Cl>C(O)(=O)C>[CH3:8][CH:7]=[C:6]([C:3]1[CH:4]=[CH:5][S:1][C:2]=1[C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)[CH2:9][CH3:10]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 498402833-(2,2'-Bithiophene-3-yl)pentan-3-ol

生成物 1

HCID 679963483-(Pent-2-en-3-yl)-2,2'-bitiophene

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

3-(2,2′-bithiophene-3-yl)pentan-3-ol (IIa) (0.100 g, 0.40 mmol) was dissolved in acetic acid (69 mL). A solution of concentrated HCl (0.28 mL) in acetic acid (15 mL) was added via syringe to the reaction mixture. The solution was refluxed for 4 h followed by an extraction with chloroform, washing and drying over MgSO4. The solvent was removed in vacuo. The residue was purified by column chromatography on silica (n-Hexane). (0.070 g, 75%).

後処理

  1. temperatureThe solution was refluxed for 4 h
  2. extractionfollowed by an extraction with chloroform
  3. washwashing
  4. dry with materialdrying over MgSO4
  5. customThe solvent was removed in vacuo
  6. customThe residue was purified by column chromatography on silica (n-Hexane)

出典と根拠

ORDレコード
ord-c408fb10b8f3415da4b6d5c154bfe0f1
出典データセット
uspto-grants-2012_12
特許番号
US08329923B2

反応ノート

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