2-Undecanone → 2-(2,2'-Bithiophene-3-yl)undecan-2-ol

HRID 2193813ノート

反応式

HRID 2193813 の反応式
Br[C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[S:8][CH:9]=[CH:10][CH:11]=1.C([Li])CCC.[CH3:17][C:18](=[O:28])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]>C(OCC)C>[S:4]1[CH:5]=[CH:6][C:2]([C:18]([OH:28])([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:17])=[C:3]1[C:7]1[S:8][CH:9]=[CH:10][CH:11]=1

参加物

5

反応物 3

HCID 81632-UndecanoneHCID 36136783-Bromo-2,2'-bithiopheneHCID 178418339Butyllithium

生成物 1

HCID 585681592-(2,2'-Bithiophene-3-yl)undecan-2-ol収率 64%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

3-Bromo-2,2′-bithiophene (IIIa) (1.00 g, 4.08 mmol) in dry diethylether (35 mL) was added slowly to a solution of n-butyllithium (1.6 M in hexane, 2.50 mL, 4.0 mmol) in dry diethylether (35 mL) at −78° C. over 2 h under N2. The mixture was stirred for 15 minutes at the same temperature. Freshly distilled 2-undecanone (0.84 mL, 4.08 mmol) was added via a syringe to the mixture at −78° C., followed by stirring overnight at room temperature. The reaction was quenched with an aqueous NH4Cl-solution (2.5 M, 20 mL) and water (20 mL) at 0° C. The organic phase was separated and the aqueous phase was extracted with diethylether. The combined organic phases were washed with brine, dried over MgSO4 and evaporated under reduced pressure to give a crude oil. The oily residue was purified by column chromatography (eluent hexane/EtOAc 90:10) to afford the title compound (IIc) as a yellow oil (0.86 g, 64%). 1H-NMR (CDCl3): δ=7.35 (dd, J=1.2 Hz, J=5.2 Hz, 1H), 7.22 (d, J=5.4 Hz, 1H), 7.12 (dd, J=1.2 Hz, J=3.5 Hz, 1H), 7.04 (d, J=5.4 Hz, 1H), 7.01 (dd, J=3.5 Hz, J=5.2 Hz, 1H), 1.49 (s, 3H), 1.38-1.15 (m, 16H), 0.96-0.80 (m, 3H). 13C-NMR (CDCl3): δ=147.34, 136.12, 130.03, 129.50, 128.64, 127.76, 127.42, 125.40, 75.74, 44.52, 32.50, 30.99, 30.50, 30.29, 30.17, 29.94, 24.83, 23.32, 14.77.

後処理

  1. stirringby stirring overnight at room temperature
  2. customThe reaction was quenched with an aqueous NH4Cl-solution (2.5 M, 20 mL) and water (20 mL) at 0° C
  3. customThe organic phase was separated
  4. extractionthe aqueous phase was extracted with diethylether
  5. washThe combined organic phases were washed with brine
  6. dry with materialdried over MgSO4
  7. customevaporated under reduced pressure
  8. customto give a crude oil
  9. customThe oily residue was purified by column chromatography (eluent hexane/EtOAc 90:10)

出典と根拠

ORDレコード
ord-f1f61c53627845f5ad07f0351dc5e1f7
出典データセット
uspto-grants-2012_12
特許番号
US08329923B2

反応ノート

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