2-(Trifluoromethoxy)benzene-1-sulfonyl chloride → Cyclopropanesulfonic acid 4-[1-oxo-8-(2-trifluoromethoxy-benzenesulfonyl)-2,8-diaza-spiro[4.5]dec-2-yl]-phenyl ester
反応式
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[F:16][C:17]([F:30])([F:29])[O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25](Cl)(=[O:27])=[O:26].[NH2:31][C:32]1[CH:37]=[CH:36][C:35]([O:38][S:39]([CH:42]2[CH2:44][CH2:43]2)(=[O:41])=[O:40])=[CH:34][CH:33]=1>>[O:5]=[C:4]1[C:6]2([CH2:7][CH2:8][N:9]([S:25]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=3[O:18][C:17]([F:30])([F:29])[F:16])(=[O:27])=[O:26])[CH2:10][CH2:11]2)[CH2:12][CH2:13][N:31]1[C:32]1[CH:37]=[CH:36][C:35]([O:38][S:39]([CH:42]2[CH2:44][CH2:43]2)(=[O:41])=[O:40])=[CH:34][CH:33]=1参加物
4
反応物 3
生成物 1
実験手順
Light brown solid. MS (ESI): 575.11 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-trifluoromethoxy-benzenesulfonyl chloride and cyclopropanesulfonic acid 4-amino-phenyl ester.