4-Bromo-2-chlorobenzotrifluoride → 8-(2-Chloro-benzenesulfonyl)-2-(3-chloro-4-trifluoromethyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194205

反応式

HRID 2194205 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:21][CH2:20][C:14]2([C:18](=[O:19])[NH:17][CH2:16][CH2:15]2)[CH2:13][CH2:12]1)(=[O:10])=[O:9].Br[C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[C:25]([Cl:33])[CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]1[CH2:21][CH2:20][C:14]2([C:18](=[O:19])[N:17]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:31])([F:32])[F:30])=[C:25]([Cl:33])[CH:24]=3)[CH2:16][CH2:15]2)[CH2:13][CH2:12]1)(=[O:9])=[O:10]

参加物

3

反応物 2

HCID 202698484-Bromo-2-chlorobenzotrifluorideHCID 595779948-(2-Chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one

生成物 1

HCID 595779088-(2-Chloro-benzenesulfonyl)-2-(3-chloro-4-trifluoromethyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

実験手順

The title compound was prepared in analogy to example 148 step F) from 8-(2-chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 148 step E or example 179 step A for an alternative synthesis) and 4-bromo-2-chloro-1-trifluoromethyl-benzene. Off-white solid. MS (ESI): 507.1 (MH+).

出典と根拠

ORDレコード
ord-a44d230aa45b4abd85d2cc4ac6b4cfe3
出典データセット
uspto-grants-2012_12
特許番号
US08329904B2

関連ノート

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