BrC[C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[C:13](=[O:16])([O-])[O-].[K+].[K+].[CH3:19]N(C)C=O.[CH3:24][C:25]1O[C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[N:27][C:26]=1[CH2:36][O:37][C:38]1[CH:58]=[CH:57][C:41]([CH2:42][N:43]2[C:55]3[CH:54]=[CH:53][CH:52]=[C:51](O)[C:50]=3[C:49]3[C:44]2=[CH:45][CH:46]=[CH:47][CH:48]=3)=[CH:40][C:39]=1[O:59][CH3:60].[OH2:61]>>[CH3:24][C:25]1[O:61][C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[N:27][C:26]=1[CH2:36][O:37][C:38]1[CH:58]=[CH:57][C:41]([CH2:42][N:43]2[C:44]3[CH:45]=[CH:46][CH:47]=[CH:48][C:49]=3[C:50]3[C:55]2=[CH:54][CH:53]=[CH:52][C:51]=3[O:16][CH2:13][C:11]2[CH:12]=[CH:3][C:4]([C:5]([O:7][CH2:8][CH3:19])=[O:6])=[CH:9][CH:10]=2)=[CH:40][C:39]=1[O:59][CH3:60]47 mg of methyl 2-bromomethylbenzoate and 27 mg of potassium carbonate (powder) were added to N,N-dimethylformamide (2 mL) solution of 98 mg of 9-{4-[(5-methyl-2-phenyloxazole-4-yl)methoxy]-3-methoxybenzyl}-9H-carbazole-4-o 1, and stirred at 90° C. for 1 hour. After the reaction mixture was allowed to cool, water was added thereto, and then extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated in vacuo, the residue was crystallized from a small amount of ethanol, isolated by filtration with n-hexane, dried under a reduced pressure, and 110 mg of the subject compound was prepared.
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