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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
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Water → HCID 67138479、化合物

HRID 2194311
ノート
印刷プレビュー

反応式

HRID 2194311 の反応式
BrC[C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[C:13](=[O:16])([O-])[O-].[K+].[K+].[CH3:19]N(C)C=O.[CH3:24][C:25]1O[C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[N:27][C:26]=1[CH2:36][O:37][C:38]1[CH:58]=[CH:57][C:41]([CH2:42][N:43]2[C:55]3[CH:54]=[CH:53][CH:52]=[C:51](O)[C:50]=3[C:49]3[C:44]2=[CH:45][CH:46]=[CH:47][CH:48]=3)=[CH:40][C:39]=1[O:59][CH3:60].[OH2:61]>>[CH3:24][C:25]1[O:61][C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[N:27][C:26]=1[CH2:36][O:37][C:38]1[CH:58]=[CH:57][C:41]([CH2:42][N:43]2[C:44]3[CH:45]=[CH:46][CH:47]=[CH:48][C:49]=3[C:50]3[C:55]2=[CH:54][CH:53]=[CH:52][C:51]=3[O:16][CH2:13][C:11]2[CH:12]=[CH:3][C:4]([C:5]([O:7][CH2:8][CH3:19])=[O:6])=[CH:9][CH:10]=2)=[CH:40][C:39]=1[O:59][CH3:60]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 5

HCID 962WaterHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 2734813Methyl 2-(bromomethyl)benzoateHCID 59571732HCID 59571732、化合物

生成物 1

HCID 67138479HCID 67138479、化合物

反応条件

温度
90 °C

実験手順

47 mg of methyl 2-bromomethylbenzoate and 27 mg of potassium carbonate (powder) were added to N,N-dimethylformamide (2 mL) solution of 98 mg of 9-{4-[(5-methyl-2-phenyloxazole-4-yl)methoxy]-3-methoxybenzyl}-9H-carbazole-4-o 1, and stirred at 90° C. for 1 hour. After the reaction mixture was allowed to cool, water was added thereto, and then extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated in vacuo, the residue was crystallized from a small amount of ethanol, isolated by filtration with n-hexane, dried under a reduced pressure, and 110 mg of the subject compound was prepared.

後処理

  1. temperatureto cool
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationAfter filtration
  6. concentrationthe filtrate was concentrated in vacuo
  7. customthe residue was crystallized from a small amount of ethanol
  8. customisolated by filtration with n-hexane
  9. dry with materialdried under a reduced pressure, and 110 mg of the subject compound
  10. customwas prepared

出典と根拠

ORDレコード
ord-8cb8cbd342e44d839e2d0839295afb53
出典データセット
uspto-grants-2012_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08329913B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート