(Chlorothio)formyl chloride → HCID 67079379、化合物
反応式
Cl[C:2]([S:4]Cl)=[O:3].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][C:15]([NH2:17])=[O:16])=[CH:9][CH:8]=1>C1(C)C=CC=CC=1>[Cl:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][CH2:14][C:15]2[O:16][C:2](=[O:3])[S:4][N:17]=2)=[CH:11][CH:12]=1参加物
4
実験手順
11.60 g (88.5 mmol) of chlorocarbonylsulphenyl chloride and 13.54 g (73.8 mmol) of 3-(4-chlorophenyl)propionamide are stirred in 25 ml of toluene at 70° C. for 3 h. Subsequently, the mixture is cooled and freed from a solvent under vacuum and the residue is purified by column chromatography. 15.6 g of product are obtained (99.9% purity, 87.6% yield, log P (pH 2.3)=3.36).
後処理
- temperatureSubsequently, the mixture is cooled
- customthe residue is purified by column chromatography
出典と根拠
- ORDレコード
- ord-d61bb4d7079244b18137299bc7eb4301
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08334235B2
反応ノート
読み込み中…