3-Methylphenylacetylene → 4-(2,5-dimethyl-4-m-tolylethynyl-imidazol-1-yl)-1H-pyridin-2-one

反応式

I[C:2]1[N:3]=[C:4]([CH3:15])[N:5]([C:8]2[CH:13]=[CH:12][NH:11][C:10](=[O:14])[CH:9]=2)[C:6]=1[CH3:7].[C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=1)#[CH:17]>>[CH3:15][C:4]1[N:5]([C:8]2[CH:13]=[CH:12][NH:11][C:10](=[O:14])[CH:9]=2)[C:6]([CH3:7])=[C:2]([C:17]#[C:16][C:18]2[CH:19]=[C:20]([CH3:24])[CH:21]=[CH:22][CH:23]=2)[N:3]=1

参加物

反応物 2

HCID 1366003-Methylphenylacetylene

HCID 668665644-(4-iodo-2,5-dimethyl-imidazol-1-yl)-1H-pyridin-2-one

生成物 1

HCID 581111894-(2,5-dimethyl-4-m-tolylethynyl-imidazol-1-yl)-1H-pyridin-2-one

実験手順

The title compound, light brown solid, MS: m/e=304.1 (M+H+), was prepared in accordance with the general method of example 21a from 4-(4-iodo-2,5-dimethyl-imidazol-1-yl)-1H-pyridin-2-one and 1-Ethynyl-3-methyl-benzene.

出典と根拠

ORDレコード: ord-fb7ab7e32a3f485abea098a2ce2b2dc4
出典データセット: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08334287B2

反応ノート

読み込み中…