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1,2-Dibromoethane → 1-{2-(2-Bromo-ethoxy)-5-chloro-3-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-6-methyl-phenyl}-ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dibromoethane | HCID 7839 | — |
| 反応物 | 1-{3-Chloro-5-[3-(4-fluoro-phenyl)-butoxy]-6-hydroxy-4-methoxy-2-methyl-phenyl}-ethanone | HCID 59583510 | — |
| 生成物 | 1-{2-(2-Bromo-ethoxy)-5-chloro-3-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-6-methyl-phenyl}-ethanone | HCID 59583523 | — |
反応手順
Example 7c (511 mg, 1.34 mmol) was reacted with 1,2-dibromoethane (20.0 eq.) as described under General Procedure F to afford the title compound (641 mg, quantitative yield) as a light brown oil. 1H NMR (300 MHz, CDCl3) δ 7.20-7.15 (m, 2H), 7.01-6.96 (m, 2H), 4.26 (t, J=6.2 Hz, 2H), 3.96 (t, J=6.6 Hz, 2H), 3.84 (s, 3H), 3.49 (t, J=6.2 Hz, 2H), 2.99 (m, 1H), 2.50 (s, 3H), 2.19 (s, 3H), 2.07-2.01 (m, 2H), 1.30 (d, J=6.9 Hz, 3H). MS (ES+) m/z 487.3 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202513B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-781b40a6dd5d48bfb7bf70ec8a99be46 |
| 出典メモ | uspto-grants-2012_06 |