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3,5-Dimethoxytoluene → 1,3-Dimethoxy-5-methyl-2-(4-phenylbutyl)benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,5-Dimethoxytoluene | HCID 77844 | — |
| 反応物 | 1-Bromo-4-phenylbutane | HCID 259668 | — |
| 生成物 | 1,3-Dimethoxy-5-methyl-2-(4-phenylbutyl)benzene | HCID 59272416 | 1,347.9% |
反応手順
3,5-Dimethoxytoluene (2.93 mL, 20 mmol) and 4-phenylbutylbromide (4.13 mL, 1.2 mmol) were reacted as described under General Procedure H and the crude product was purified by flash chromatography (silica-gel, petroleum ether/EtOAc 200:1) to afford the product as a clear oil (4.6 g, 81%). 1H NMR (300 MHz, CDCl3) δ 7.13-7.22 (m, 5H), 6.34 (s, 2H), 3.76 (s, 6H), 2.60-2.64 (m, 4H), 2.31 (s, 3H), 1.53-1.67 (m, 4H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202513B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-4e237ef6eccd47009826cbfcff19c7e9 |
| 出典メモ | uspto-grants-2012_06 |