1,2-Dibromoethane → 1-[2-(2-Bromo-ethoxy)-5-chloro-4-methoxy-6-methyl-3-(3-phenyl-propoxy)-phenyl]-ethanone

HRID 219471

反応式

HRID 219471 の反応式
[Cl:1][C:2]1[C:3]([CH3:24])=[C:4]([C:21](=[O:23])[CH3:22])[C:5]([OH:20])=[C:6]([O:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:7]=1[O:8][CH3:9].[Br:25][CH2:26][CH2:27]Br>>[Br:25][CH2:26][CH2:27][O:20][C:5]1[C:6]([O:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:7]([O:8][CH3:9])[C:2]([Cl:1])=[C:3]([CH3:24])[C:4]=1[C:21](=[O:23])[CH3:22]

参加物

3

反応物 2

HCID 78391,2-DibromoethaneHCID 595835181-[3-Chloro-6-hydroxy-4-methoxy-2-methyl-5-(3-phenyl-propoxy)-phenyl]-ethanone

生成物 1

HCID 595834951-[2-(2-Bromo-ethoxy)-5-chloro-4-methoxy-6-methyl-3-(3-phenyl-propoxy)-phenyl]-ethanone収率 100%

実験手順

Example 34a (4.3 g, 17 mmol) was reacted with 1,2-dibromoethane (40 mL) as described under General Procedure F to afford the title compound (5.5 g, 100%) as a red oil. 1H NMR (300 MHz, CDCl3) δ 7.33-7.18 (m, 5H), 4.30 (t, J=6.3 Hz, 2H), 4.09 (t, J=6.3 Hz, 2H), 3.89 (s, 3H), 3.51 (t, J=6.0 Hz, 2H), 2.83 (t, J=8.1 Hz, 2H), 2.52 (s, 3H), 2.20 (s, 3H), 2.14-2.05 (m, 2H). MS (ES+) m/z 457 (M+H+).

出典と根拠

ORDレコード
ord-b1410242522548a39c38688c37dfb1a0
出典データセット
uspto-grants-2012_06
特許番号
US08202513B2

関連ノート

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