Sulfuric Acid → Methyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([OH:16])=[O:15])[CH2:9]2)=[CH:4][CH:3]=1.[CH2:17](Cl)Cl.OS(O)(=O)=O>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([O:16][CH3:17])=[O:15])[CH2:9]2)=[CH:6][CH:7]=1参加物
5
実験手順
To 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid 51 was added 80 mL of CH2Cl2, 30 mL of MeOH, and 1.0 mL of concentrated H2SO4. After heating at reflux overnight, the mixture concentrated and triturated with water to give methyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate 52.
後処理
- temperatureAfter heating
- temperatureat reflux overnight
- concentrationthe mixture concentrated
- customtriturated with water
出典と根拠
- ORDレコード
- ord-2cc664b3ae924667a33cba9c70007ba2
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08334317B2
反応ノート
読み込み中…