Diethyl Ether → 1-Acetyl-5-(acetyloxy)-6-bromo-1H-indazole

HRID 2195504ノート

反応式

HRID 2195504 の反応式
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[CH:4][C:3]=1[OH:11].C([O:14][CH2:15][CH3:16])C.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([O:11][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:2]=1[Br:1])[N:8]([C:15](=[O:14])[CH3:16])[N:7]=[CH:6]2)(=[O:19])[CH3:18]

参加物

4

反応物 3

HCID 3283Diethyl EtherHCID 7918Acetic AnhydrideHCID 591599466-Bromo-1H-indazol-5-ol

生成物 1

HCID 667671231-Acetyl-5-(acetyloxy)-6-bromo-1H-indazole収率 98%

反応条件

温度
110 °C

実験手順

A mixture of 6-bromo-5-hydroxy-1H-indazole (25 g, 117 mmol) in acetic acid anhydride (75 mL) is heated at 110° C. with stirring for 2 hours. After it is cooled, diethyl ether (100 mL) is added. The precipitate is collected by filtration, washed with diethyl ether (30 mL), and dried under vacuum to afford the product (34 g, 98% yield). MS (m/z): 297.0 (M+H).

後処理

  1. temperatureAfter it is cooled
  2. filtrationThe precipitate is collected by filtration
  3. washwashed with diethyl ether (30 mL)
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-1245610d97b54ce0b13512a909201393
出典データセット
uspto-grants-2012_12
特許番号
USRE043878E1

反応ノート

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