Pioglitazone Hydrochloride → Pioglitazone

HRID 2195571ノート

反応式

HRID 2195571 の反応式
[CH3:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][O:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH:19]3[S:25][C:23](=[O:24])[NH:22][C:20]3=[O:21])=[CH:16][CH:17]=2)=[N:7][CH:8]=1.Cl>C(O)(=O)C(C)O.C(O)(=O)CO.CC(C)=O.CO>[CH3:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][O:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH:19]3[S:25][C:23](=[O:24])[NH:22][C:20]3=[O:21])=[CH:16][CH:17]=2)=[N:7][CH:8]=1

参加物

5

反応物 1

HCID 60560Pioglitazone Hydrochloride

生成物 1

HCID 4829Pioglitazone

試薬・触媒・溶媒 3

HCID 180Acetone溶媒HCID 887Methanol溶媒HCID 36797Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)溶媒

実験手順

An aqueous solution of 0.5 wt % polyvinyl alcohol (Gosenol EG-05 (registered trademark), manufactured by The Nippon Synthetic Chemical Industry Co., Ltd.) was prepared and used as a poor solvent. In addition, lactic acid-glycolic acid copolymer (PLGA7520, lactic acid/glycolic acid=75/25, weight average molecular weight 20,000, Wako Pure Chemical Industries, Ltd.) (1 g) was dissolved in acetone (40 mL) and mixed with pioglitazone hydrochloride (40 mg) in methanol (20 mL), and the mixture was used as a polymer solution. The solution was added dropwise at 4 mL/min to the earlier-obtained poor solvent at 40° C. with stirring at 400 rpm to give a pioglitazone-containing PLGA nanoparticle suspension. Acetone and methanol were evaporated under reduced pressure for 1.5 hr, and the residue was freeze-dried to give a pioglitazone-containing PLGA nanoparticle powder.

後処理

  1. custom) was prepared
  2. additionThe solution was added dropwise at 4 mL/min to the earlier-obtained poor solvent at 40° C.

出典と根拠

ORDレコード
ord-e2aa05dda6034318a473f6182cf9c106
出典データセット
uspto-grants-2012_12
特許番号
US08337896B2

反応ノート

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