化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Quinolinepropionic acid, 1,2,3,4-tetrahydro-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 反応物 | Dimethyl sulfoxide methanol | HCID 22036561 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | Quinolinepropionic acid, 1,2,3,4-tetrahydro- | HCID 98707 | — |
反応手順
A mixture of the corresponding acid (0.2 mmol), amine (0.2 mmol), triethylamine (28 μL, 0.2 mmol) and HATU (76 mg, 0.2 mmol) in pyridine (0.5 mL) was microwaved at 200° C. for 420 s. The reaction mixture was diluted with 50% DMSO/MeOH (0.5 mL), filtered and purified by HPLC (gradient of 10-99% CH3CN/water).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202861B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-ac3770e1be064b4dbb752ea7ef32733d |
| 出典メモ | uspto-grants-2012_06 |