Hydrochloric Acid → 2-nitro-5-piperazin-1-yl-benzoic Acid
反応式
[N+:1]([C:4]1[CH:12]=[CH:11][C:10](Cl)=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-:3])=[O:2].[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.Cl>O>[N+:1]([C:4]1[CH:12]=[CH:11][C:10]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-:3])=[O:2]参加物
5
実験手順
To the suspension of 50 g 2-nitro-5-chlorobenzoic acid in 750 ml water, 86 g of piperazine is added and the reaction mixture is heated at reflux temperature for 20 hours. The mixture is then neutralized with conc. hydrochloric acid and the precipitated crystalline material is filtered off and dried to obtain 62 g title compound (MH+: 252)
後処理
- additionis added
- temperaturethe reaction mixture is heated
- temperatureat reflux temperature for 20 hours
- filtrationthe precipitated crystalline material is filtered off
- customdried
出典と根拠
- ORDレコード
- ord-849456b97daf4633bb5ea947dff32749
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08338411B2
反応ノート
読み込み中…