Benzylamine → 2-Amino-3-cyano-4-benzylamino-6-(4-acetylpiperazin-1-yl)quinoline
反応式
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]3[CH2:20][CH2:19][N:18]([C:21](=[O:23])[CH3:22])[CH2:17][CH2:16]3)[CH:8]=2)[N:3]=1.[CH2:24]([NH2:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:31][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]3[CH2:20][CH2:19][N:18]([C:21](=[O:23])[CH3:22])[CH2:17][CH2:16]3)[CH:8]=2)[N:3]=1参加物
4
実験手順
5 g 2-amino-3-cyano-4-chloro-6-(4-acetylpiperazin-1-yl)quinoline and 15 ml benzylamine is stirred at 125° C. for 1 h. The reaction mixture is then poured onto 30 ml water, the resulting precipitate is filtered off, washed with 20 ml water and dried to obtain 4 g of the title compound (MH+: 401).