4-Aminocyclohexanecarboxylic acid → HCID 178525767、化合物

HRID 219602

反応式

HRID 219602 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[C:11]([C:19]2[O:23][N:22]=[C:21]([C:24]3[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=3)[N:20]=2)[N:10]=[N:9]1.[NH2:32][CH:33]1[CH2:38][CH2:37][CH:36]([C:39]([OH:41])=[O:40])[CH2:35][CH2:34]1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([C:13]2[CH:14]=[CH:15][N:16]=[CH:17][CH:18]=2)=[C:11]([C:19]2[O:23][N:22]=[C:21]([C:24]3[CH:25]=[CH:26][C:27]([CH2:28][NH:32][C@H:33]4[CH2:38][CH2:37][C@H:36]([C:39]([OH:41])=[O:40])[CH2:35][CH2:34]4)=[CH:30][CH:31]=3)[N:20]=2)[N:10]=[N:9]1

参加物

3

反応物 2

HCID 1715604-Aminocyclohexanecarboxylic acidHCID 866481594-(5-(1-(2-fluorophenyl)-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-3-yl) benzaldehyde

生成物 1

HCID 178525767HCID 178525767、化合物

実験手順

The title compound was prepared following the procedure described for Example 94, but starting from 4-(5-(1-(2-fluorophenyl)-5-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde, obtained as described in Example 113, Step 1, (200 mg; 0.48 mmol) and 4-aminocyclohexanecarboxylic acid (138 mg; 0.97 mmol), to give Example 168 as a white solid. 1H NMR: (DMSO-d6, 400 MHz) δ 8.76-8.73 (2H, m), 7.95-7.88 (3H, m), 7.76-7.69 (1H, m), 7.64-7.49 (6H, m), 3.81 (2H, s), 2.58 (1H, d, J=5.6 Hz), 2.35 (1H, d, J=6.4 Hz), 1.96-1.85 (2H, m), 1.60 (2H, t, J=10.0 Hz), 1.53-1.44 (4H, m). LC/MS (Method C): 540 (M+H)+. HPLC (Method I) Rt 11.49 min (Purity: 93.8%).

後処理

  1. customobtained

出典と根拠

ORDレコード
ord-e96c55cb7cec48f385c77342929532a0
出典データセット
uspto-grants-2012_06
特許番号
US08202856B2

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