化工社化工社 化学情報印刷レポート · 研究参考用
HRID 2196093作成日：2026年10月27日
2,3-Dihydroxy-4-methoxybenzoic acid → 7-Methoxy-1'-acetyl-spiro[1,3-benzodioxole-2,4'-piperidine]-4-carboxylic acid
https://huagongshe.com/reaction/2196093
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,3-Dihydroxy-4-methoxybenzoic acid | HCID 77534 | — |
| 反応物 | 1-Acetyl-4,4-dimethoxy-piperidine | HCID 12653646 | — |
| 反応物 | 1-Acetyl-4-methoxy-1,2,3,6-tetrahydropyridine | HCID 18799218 | — |
| 生成物 | 7-Methoxy-1'-acetyl-spiro[1,3-benzodioxole-2,4'-piperidine]-4-carboxylic acid | HCID 59286727 | 26.3% |
反応手順
A mixture of 2,3-dihydroxy-4-methoxybenzoic acid (1.23 g, 6.67 mmol), 1-acetyl-4,4-dimethoxy-piperidine (1.4 g, 7.6 mmol) and 1-acetyl-1,2,3,6-tetrahydro-4-methoxy-pyridine (14.2 g, 91.5 mmol) was exposed to microwave heating (180° C., one hour) in a sealed reaction vessel. Filtration and subsequent standard HPLC purification afforded compound 508 (0.54 g, 26%). LC/MS (METHOD B): (m/z) 308.2 (MH+); RT=2.27 min; purity (UV)=95%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08338431B2 |
|---|
| 出典データセット | uspto-grants-2012_12 |
|---|
| ORD ID | ord-e9fd4a743a404e43a1011bb7e10de4ca |
|---|
| 出典メモ | uspto-grants-2012_12 |
|---|
