関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Nicotinamidine hydrochloride | HCID 202042 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | 3,3-Dimethoxy-2-methoxycarbonylpropen-1-ol | HCID 59117939 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Pyridin-3-yl-pyrimidine-5-carboxylic acid methyl ester | HCID 68556527 | 51.2% |
反応手順
To a solution of nicotinamidine hydrochloride (1 g, 6.35 mmol) in anhydrous DMF (12 mL) is added sodium salt of 2-dimethoxymethyl-3-hydroxy-acrylic acid methyl ester (1.46 g, 7.36 mmol) and the reaction mixture is heated at 100° C. under N2 for 3 hours. After this time the reaction is cooled to room temperature and water (48 mL) is added. The precipitate is collected by filtration, washed with water and vacuum dried to afford 2-pyridin-3-yl-pyrimidine-5-carboxylic acid methyl ester (0.7 g, 51%). MS: 216 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08202863B2 |
|---|
| 出典データセット | uspto-grants-2012_06 |
|---|
| ORD ID | ord-589daa2ddd0e4a7bb46476bd0c62144d |
|---|
| 出典メモ | uspto-grants-2012_06 |
|---|
