関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Amino-5-bromopyridine | HCID 70622 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 1-(Benzofuran-3-yl)-2-bromoethanone | HCID 2776580 | — |
| 溶媒 | 1-Propanol | HCID 1031 | — |
| 生成物 | 2-(Benzofuran-3-yl)-6-bromoimidazo[1,2-a]pyridine | HCID 68640089 | 76.3% |
反応手順
In a glass tube, 250 mg of 1-(benzofuran-3-yl)-2-bromoethanone, 181 mg of 5-bromopyridin-2-ylamine and 105 mg of sodium hydrogencarbonate are dissolved in 15 ml of n-propanol. The tube is closed and heated at 80° C. for 20 h. After cooling, 20 ml of water are added and the reaction mixture is stirred for 1 hour at ambient temperature. A precipitate forms, and is recovered by filtration, washed with water and then with diisopropyl ether, and dried in a desiccator under reduced pressure. 250 mg of compound are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08338451B2 |
|---|
| 出典データセット | uspto-grants-2012_12 |
|---|
| ORD ID | ord-d9ba4379f2634dfd9d2d565c0af60c07 |
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| 出典メモ | uspto-grants-2012_12 |
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