Water → 2-(Benzofuran-3-yl)-6-bromoimidazo[1,2-a]pyridine

HRID 2196449

反応式

HRID 2196449 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.C(=O)([O-])O.[Na+].O.[O:15]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[C:17]([C:24](=O)[CH2:25]Br)=[CH:16]1>C(O)CC>[O:15]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[C:17]([C:24]2[N:8]=[C:5]3[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]3[CH:25]=2)=[CH:16]1

参加物

6

反応物 4

HCID 962WaterHCID 706222-Amino-5-bromopyridineHCID 516892Sodium BicarbonateHCID 27765801-(Benzofuran-3-yl)-2-bromoethanone

生成物 1

HCID 686400892-(Benzofuran-3-yl)-6-bromoimidazo[1,2-a]pyridine収率 76.3%

試薬・触媒・溶媒 1

HCID 10311-Propanol溶媒

反応条件

温度
80 °C

実験手順

In a glass tube, 250 mg of 1-(benzofuran-3-yl)-2-bromoethanone, 181 mg of 5-bromopyridin-2-ylamine and 105 mg of sodium hydrogencarbonate are dissolved in 15 ml of n-propanol. The tube is closed and heated at 80° C. for 20 h. After cooling, 20 ml of water are added and the reaction mixture is stirred for 1 hour at ambient temperature. A precipitate forms, and is recovered by filtration, washed with water and then with diisopropyl ether, and dried in a desiccator under reduced pressure. 250 mg of compound are obtained.

後処理

  1. customThe tube is closed
  2. temperatureAfter cooling
  3. filtrationA precipitate forms, and is recovered by filtration
  4. washwashed with water
  5. dry with materialwith diisopropyl ether, and dried in a desiccator under reduced pressure

出典と根拠

ORDレコード
ord-d9ba4379f2634dfd9d2d565c0af60c07
出典データセット
uspto-grants-2012_12
特許番号
US08338451B2

関連ノート

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