Hydrochloric Acid → [3-(3-Methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol hydrochloride

HRID 2196455ノート

反応式

HRID 2196455 の反応式
[CH3:1][C:2]1[N:6]2[CH:7]=[C:8]([C:11]3[CH:12]=[C:13]([CH2:17][OH:18])[CH:14]=[CH:15][CH:16]=3)[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[C:19]1[S:20][CH:21]=[CH:22][CH:23]=1.[ClH:24]>ClCCl.CO.C(O)(C)C>[ClH:24].[CH3:1][C:2]1[N:6]2[CH:7]=[C:8]([C:11]3[CH:12]=[C:13]([CH2:17][OH:18])[CH:14]=[CH:15][CH:16]=3)[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[C:19]1[S:20][CH:21]=[CH:22][CH:23]=1

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 44231018[3-(3-Methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol

生成物 1

HCID 44231017[3-(3-Methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol hydrochloride

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 3776Isopropanol溶媒HCID 6344Dichloromethane溶媒

実験手順

140 mg of [3-(3-methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol are suspended in dichloromethane and methanol; 3.2 ml of a 0.1N solution of hydrochloric acid in isopropanol are added thereto, dropwise. The reaction mixture is then concentrated under reduced pressure. The residual solid is taken up in diethyl ether, and the precipitate is recovered by filtration and oven-dried under reduced pressure. 150 mg of compound are obtained.

後処理

  1. concentrationThe reaction mixture is then concentrated under reduced pressure
  2. filtrationthe precipitate is recovered by filtration
  3. customoven-dried under reduced pressure

出典と根拠

ORDレコード
ord-15135a70d3f345c7aa492b4069a6eab4
出典データセット
uspto-grants-2012_12
特許番号
US08338451B2

反応ノート

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