関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | 4-Nitrothiophene-2-carbaldehyde | HCID 818857 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 4-Nitrothiophene-2-carbonitrile | HCID 819044 | 68% |
反応手順
Acetic anhydride (1.2 mL) was added to a mixture of aldehyde 1 (314.3 mg, 2.00 mmol) and hydroxylamine hydrochloride (277.6 mg, 4.00 mmol) in pyridine (1.5 mL) pre-heated at 95° C. according to the procedure of M. Bobosikova et al. (J. Chem. Soc., Perkin Trans. I, 2001, 680-689). After 2 h at 95° C. the mixture was cooled and poured over ice and the precipitate was filtered out and allowed to air dry. Nitrile 2 was obtained in 68% yield as beige solid 1H NMR (CDCl3) δ(ppm): 8.51 (s, 1H), 8.14 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08338437B2 |
|---|
| 出典データセット | uspto-grants-2012_12 |
|---|
| ORD ID | ord-e5a193ca93074e70b905fe9ec4a66206 |
|---|
| 出典メモ | uspto-grants-2012_12 |
|---|
