Di-tert-butyl 1-(5-formylthiophen-2-yl)hydrazine-1,2-dicarboxylate → Di-tert-butyl 1-(5-cyanothiophen-2-yl)hydrazine-1,2-dicarboxylate

HRID 2196509ノート

反応式

HRID 2196509 の反応式
[C:1]([C:3]1[S:7][CH:6]=[C:5](N(C(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)[CH:4]=1)#[N:2].C(C1SC([N:31]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[NH:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])=CC=1)=O>>[C:1]([C:3]1[S:7][C:6]([N:31]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[NH:32][C:33]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:34])=[CH:5][CH:4]=1)#[N:2]

参加物

3

反応物 2

HCID 59843212Di-tert-butyl 1-(5-formylthiophen-2-yl)hydrazine-1,2-dicarboxylateHCID 59843278Di-tert-butyl 1-(5-cyanothiophen-3-yl)hydrazine-1,2-dicarboxylate

生成物 1

HCID 59843233Di-tert-butyl 1-(5-cyanothiophen-2-yl)hydrazine-1,2-dicarboxylate収率 75%

実験手順

Following the same procedure as described for compound 12 (step 2, scheme 2, example 1c) except using 19 (935 mg, 2.73 mmol) instead of 11 to provide compound 20 (692 mg, 75%) as a yellow solid. LRMS (ESI): calc. 339.1; found 340.2 (MH)+.

出典と根拠

ORDレコード
ord-e891dd38a3ce451e965553d98f67a34a
出典データセット
uspto-grants-2012_12
特許番号
US08338437B2

反応ノート

読み込み中…