methyl-(R)-4-(1-carbamoylpropylamino)butyrate → Etiracetam, (R)-

HRID 2197663ノート

反応式

HRID 2197663 の反応式
C[O:2][C:3](=O)[CH2:4][CH2:5][CH2:6][NH:7][C@@H:8]([C:11](=[O:13])[NH2:12])[CH2:9][CH3:10]>C1(C)C=CC=CC=1>[O:2]=[C:3]1[CH2:4][CH2:5][CH2:6][N:7]1[C@H:8]([CH2:9][CH3:10])[C:11]([NH2:12])=[O:13]

参加物

3

反応物 1

HCID 59650081methyl-(R)-4-(1-carbamoylpropylamino)butyrate

生成物 1

HCID 441341Etiracetam, (R)-収率 30%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

To the crude methyl-(R)-4-(1-carbamoylpropylamino)butyrate (VIf) in toluene (20 ml) is added 2-hydroxypyrridine (50 mg, 10 mol %). The mixture is heated to 80° C. until complete conversion. After 16 hours (GC: 100% conversion) the mixture is concentrated to dryness to yield (R)-2-(2-oxopyrrolidin-1-yl)butyramide (0.28 g, 1.6 mmol, 30%, yield determination by GC assay from pure standard).

後処理

  1. concentrationAfter 16 hours (GC: 100% conversion) the mixture is concentrated to dryness

出典と根拠

ORDレコード
ord-4366f7dfe47c471d9ff801267fc62ee2
出典データセット
uspto-grants-2012_12
特許番号
US08338621B2

反応ノート

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