Ammonium Hydroxide → 3-(4-Chloro-2-nitro-phenoxy)-benzamide
反応式
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=2)[C:10](Cl)=[O:11])=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1.[NH4+:21].[OH-]>O>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=2)[C:10]([NH2:21])=[O:11])=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1参加物
4
実験手順
The product from Example 168b (1.8 g, 6.13 mmol) was added to cold NH4OH (15 mL) and stirred for 1 h. The reaction was poured into water and extracted with ethyl acetate. The organic layer washed with water, brine, and dried over sodium sulfate, filtered and concentrated under vacuum to gave the title compound (1.66 g, 92%).
後処理
- extractionextracted with ethyl acetate
- washThe organic layer washed with water, brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-068e560d494046b1aa74b731c8ec7b13
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08338605B2
反応ノート
読み込み中…