4-Bromo-2-chloro-alpha,alpha,alpha-trifluorotoluene → HCID 67022225、化合物

反応式

Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.[NH:13]1[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:14]1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([N:13]2[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:14]2)=[CH:3][C:4]=1[C:9]([F:12])([F:11])[F:10]

参加物

反応物 2

HCID 679594-Bromo-2-chloro-alpha,alpha,alpha-trifluorotoluene

HCID 53428732Ethyl 3-(pyrrolidin-3-YL)propanoate

生成物 1

HCID 67022225HCID 67022225、化合物収率 61%

実験手順

The title compound (5.0 g, yield 61%) was obtained from 4-bromo-1-chloro-2-(trifluoromethyl)benzene and ethyl 3-(pyrrolidin-3-yl)propanoate obtained in Reference Example 12 by a method similar to that in Reference Example 1.

出典と根拠

ORDレコード: ord-0216687dcc0048598625a2ece54bc722
出典データセット: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08338622B2

反応ノート

読み込み中…